Breakouts & acne
The concern with the most prescription-grade science. Several over-the-counter actives are genuinely effective for mild-to-moderate breakouts.
What has evidence, ranked
01Azelaic Acid
Strong evidenceOne of the best-proven non-prescription acne routes
02Niacinamide
Good evidence4% gel performed on par with a prescription antibiotic
03Salicylic Acid (BHA)
Good evidenceDecades of use, FDA-recognized, moderate trial base
04Retinol
Early evidencePlausible, but the acne trials used prescription retinoids
Sample products that cover it
From the demo catalog — ranked by their best evidence for breakouts.
Paula's Choice
10% Azelaic Acid Booster
Strong evidence
The Ordinary
Azelaic Acid Suspension 10%
Strong evidence
CeraVe
Resurfacing Retinol Serum
Good evidence
La Roche-Posay
Niacinamide 10 Serum
Good evidence
La Roche-Posay
Pure Vitamin C10 Serum
Good evidence
La Roche-Posay
Retinol B3 Serum
Good evidence
Honest note: harsher isn't better
Scrubbing and over-cleansing worsen acne by damaging the barrier. Toothpaste on a pimple is a myth that irritates. If breakouts are severe or scarring, a dermatologist beats any serum — OTC has real limits.
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