Breakouts
Good evidenceDecades of use, FDA-recognized, moderate trial base
Salicylic acid 0.5–2% is an FDA OTC-monograph acne ingredient — a regulatory recognition of efficacy — and controlled trials show reduced comedones within 4–12 weeks. It's generally gentler than benzoyl peroxide; head-to-head comparisons are few, and guidelines rate the overall evidence behind it as weaker than benzoyl peroxide's.
The receipts
39 trials/reviews indexed · showing most cited- Meta-analysisJ Am Acad Dermatol· 2010· cited 39×
Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne.
- Randomized trialSkin Pharmacol Physiol· 2006· cited 36×
'Keratolytic' properties of benzoyl peroxide and retinoic acid resemble salicylic acid in man.
- Randomized trialCutis· 1981· cited 24×
Treatment of mild and moderate acne vulgaris with salicylic acid in an alcohol-detergent vehicle.
- Randomized trialJ Cosmet Dermatol· 2020· cited 23×
Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris.
- Randomized trialCutan Ocul Toxicol· 2019· cited 23×
Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study.
- Meta-analysisCochrane Database Syst Rev· 2020· cited 23×
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.