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Centella (Madecassoside)

MADECASSOSIDE

The K-beauty soother from Centella asiatica — traditional wound-healing roots, modern calming claims, modest trials.

antioxidantskin conditioningCAS 34540-22-2

Why it works

Madecassoside, the key active from Centella asiatica (tiger grass), dampens inflammatory signaling and supports collagen synthesis in wound models — the basis for its use in calming irritated, compromised skin.

Concentration matters

Products range widely; trials rarely state doses clearly.

The evidence, by concern

Redness

Early evidence

Plausible calmer with small supportive studies

How sure are we
early
How much it helps
subtle
Do studies agree
mostly agree

Small controlled studies (often in combination products, e.g. with panthenol or hyaluronic acid) show reduced redness and faster recovery of irritated skin. Encouraging but rarely tested alone, so the specific credit is hard to assign.

Safety, without the fear

Anchored to regulatory assessments — not hazard lists. Dose makes the poison; these are the conclusions at real-world cosmetic use.

Editor's note

Very well tolerated; rare contact allergy to Centella extracts is documented but uncommon.

Spotted an error, or a study we missed? Evidence content is drafted with AI assistance and pending expert review — this demo shows the format, not final copy.