Wrinkles & aging
Good evidence12% improved firmness and fine wrinkling in controlled testing
A three-month controlled comparison found 12% lactic acid increased skin firmness and thickness and improved fine lines, while 5% changed only the surface; a separate 22-week vehicle-controlled trial of 8% lactic acid confirmed photoaging improvement versus vehicle.
The receipts
27 trials/reviews indexed · showing most cited- Randomized trialArch Dermatol· 1996· cited 66×
Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial.
- Randomized trialJ Am Acad Dermatol· 2010· cited 65×
A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles.
- Randomized trialDermatol Surg· 2019· cited 40×
Randomized, Controlled, Multicentered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid for Improving Skin Quality.
- Randomized trialClin Exp Dermatol· 2015· cited 25×
Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator-blinded, comparative study.
- Randomized trialJ Drugs Dermatol· 2024· cited 14×
Effectiveness and Safety of Sculptra Poly-L-Lactic Acid Injectable Implant in the Correction of Cheek Wrinkles.
- Randomized trialAesthet Surg J· 2024· cited 12×
A Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for Nasolabial Fold Augmentation.