Redness
Early evidenceA gentle soother with more history than trial data
Allantoin appears in barrier creams that calm irritation in small studies, but it is almost never tested alone. Rated honestly: plausible mechanism, long safe history, thin isolated evidence.
The receipts
6 trials/reviews indexed · showing most cited- Randomized trialMed Oral Patol Oral Cir Bucal· 2016· cited 35×
The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction.
- Randomized trialOrphanet J Rare Dis· 2020· cited 15×
Efficacy and tolerability of the investigational topical cream SD-101 (6% allantoin) in patients with epidermolysis bullosa: a phase 3, randomized, double-blind, vehicle-controlled trial (ESSENCE study).
- Randomized trialAesthetic Plast Surg· 2018· cited 12×
Effectiveness and Safety of an Overnight Patch Containing Allium cepa Extract and Allantoin for Post-Dermatologic Surgery Scars.
- Randomized trialJ Cosmet Dermatol· 2022· cited 9×
A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo.
- Randomized trialRadiat Oncol· 2012· cited 7×
A double-blind randomised controlled trial of a natural oil-based emulsion (Moogoo Udder Cream®) containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer.
- Randomized trialJ Cosmet Dermatol· 2025· cited 0×
Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel (Main Components: Onion Extract Quercetin) for the Treatment of Rosacea.